Robbie Keane and Jonathan Walters will start up front for the Republic of Ireland as they look to move into third in Group D with a win over Gibraltar.
Everton full-back Seamus Coleman has been left on the bench for the game at the Estadio Algarve, while Eunan O'Kane and Adam Rooney have been left out of the matchday squad.
Robbie Brady and Cyrus Christie join John O'Shea and Aston Villa's Ciaran Clark in the back four.
Shay Given has been selected in goal by manager Martin O'Neill, with Darren Randolph and David Forde in reserve.
Meanwhile, Gibraltar will have brothers Lee Casciaro and Kyle Casciaro in the same side, with captain Roy Chipolina lining up in defence.
Gibraltar: Perez; R Chipolina, Sergeant, J Chipolina, L Casciaro, K Casciaro, Walker, Barnett, Bardon, Duarte, Garcia
Republic of Ireland: Given; Christie, O'Shea, Clark, Brady, McCarthy, Whelan, Hendrick, Hoolahan, Walters, Keane
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