Andrew Garfield, Jamie Foxx and Dane DeHaan will all appear at a panel for The Amazing Spider-Man 2 at Comic-Con.
In the sequel - due for release May 2, 2014 - Spidey (Garfield) faces a challenge from new villain Electro (Foxx) while juggling his complicated relationship with Gwen (Emma Stone).
Chronicle star DeHaan has joined the cast as Peter Parker's old friend Harry Osborn, who returns with new clues about Parker's past.
Also appearing at the Hall H panel are director Marc Webb and producers Avi Arad and Matt Tolmach.
Sony recently confirmed a further two sequels for June 2016 and May 2018 respectively.